Promising Developments in Treating Multiple Myeloma Coming at This Year’s AACR Meeting March 14, 2022 - Baystreet.ca VANCOUVER – USA News Group –According to a report from ResearchAndMarkets.com, total cases of the uncommon but deadly blood cancer, multiple myeloma, will continue to rise by 2030. Treatment for the condition falls under the Hematological Malignacies Drugs Market, which InsightAce Analytic projects to reach $42.78 billion by 2030, rapidly growing at a CAGR of 13.7% during the forecast period. The Blood Cancer Drugs Market is expected to hit $89.91 billion by 2028, according to a new study by Polaris Market Research. Heading into the American Association for Cancer Research (AACR) Annual Meeting 2022, one of the year’s top meetings on cancer drugs, and coming on the heels of the FDA’s latest approval for Johnson & Johnson’s (NYSE:JNJ) subsidiary’s new therapy, there’s plenty of optimism in the air for multiple myeloma treatment. Now the biotech sector is gearing up to present results at the AACR meeting in this field, including updates from Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), Compugen Ltd. (NASDAQ:CGEN), C4 Therapeutics, Inc. (NASDAQ:CCCC), and Amgen Inc. (NASDAQ:AMGN). One of the presenters set to deliver results at the AACR Annual Meeting in New Orleans between April 8-13, is Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), which has announced phase 1b data demonstrating clinical proof-of-concept for pelareorep-proteasome inhibitor combination therapy in multiple myeloma. Its flagship asset, pelareorep, is an intravenously delivered immunotherapeutic agent that induces anti-cancer immune responses and promotes an inflamed tumor phenotype—turning “cold” tumors “hot”—through innate and adaptive immune responses to treat a variety of cancers. The AACR data are from a completed phase 1b trial evaluating the combination of pelareorep and the proteasome inhibitor bortezomib in relapsed/refractory multiple myeloma patients. Results from the trial showed that the combination was well-tolerated and led to prolonged progression-free survival (PFS) of over three years in a subset of patients. Additionally, biomarker data demonstrated increased infiltration of T and NK cells in the tumor immune microenvironment post-treatment. "To see patients resistant to prior therapies achieve multi-year PFS is a remarkable finding that speaks to pelareorep's potential to synergistically combine with anti-cancer agents and provide sustained clinical benefit," said Kevin Kelly, M.D., Ph.D., Associate Professor of Clinical Medicine at the Keck School of Medicine of the University of Southern California and Principal Investigator of the trial. The AACR data shows post-treatment increases in anti-cancer immune cells correlated with both clinical response and changes in T cell clonality, which has previously been identified as a potential predictive biomarker that could increase the likelihood of success in future trials of pelareorep by informing patient selection. "These are exciting results that we believe bode well for successful outcomes in our two ongoing multiple myeloma studies that are evaluating pelareorep in combination with a next-generation proteasome inhibitor,” said Thomas Heineman, M.D., Ph.D., Chief Medical Officer of Oncolytics Biotech. Back in December 2021, Oncolytics Biotech announced preclinical data demonstrating the drug’s synergistic anti-leukemic effects when combined with the chemotherapeutic agent azacytidine. Oncolytics continues to build on data from the completed multiple myeloma trial through the advancement of two ongoing phase 1 trials of pelareorep in this indication. Also at the AACR Meeting, pioneer in computational target discovery, Compugen Ltd. (NASDAQ:CGEN), is set to present new research suggesting that targeting DNAM-1 axis receptors (PVRIG and TIGIT) holds promise for treatment of multiple myeloma. In particular, the data shows PVRIG is the most dominant immune checkpoint in these patients. "We continue to lead groundbreaking research on the biology of the key targets of the DNAM-1 axis PVRIG and TIGIT,” said Anat Cohen-Dayag, Ph.D., President and CEO of Compugen. “These data support our hypothesis that therapies targeting the DNAM-1 axis may provide new treatment options for certain cancer patients." Clinical-stage biopharmaceutical company C4 Therapeutics, Inc. (NASDAQ:CCCC) will also present a poster and three oral presentations at the meeting. Among their presentations, two pertain to multiple myeloma, including a presentation on the results of the initial treatment cohort from a First-in-Human (FIH) Phase 1/2 Study of its novel IKZF1/3 Degrader, CFT7455. “We look forward to the AACR Annual Meeting, where we will share clinical data from Cohort A in our Phase 1/2 trial evaluating CFT7455 in hematologic malignancies, as well as pre-clinical data from three programs that demonstrate differentiation and versatility of our TORPEDO platform,” said Andrew Hirsch, CEO of C4 Therapeutics. C4T will also present pre-clinical data characterizing the chemical structure of CFT7455 and the resulting improvements in potency and optimized PK properties. Amgen Inc. (NASDAQ:AMGN) has announced that new data from across its oncology portfolio and pipeline will be presented at the meeting, including an abstract on the BiTE Platform, and an evaluation of a dual-targeting BCMA-CS1 HLE BiTE molecule for multiple myeloma. Last December, Amgen received FDA approval for the expansion of the KYPROLIS (carfilzomib) US prescribing information to include its use in combination with DARZALEX FASPRO (daratumumab and hyaluronidase-fihj) and dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy. "I am pleased that the addition of subcutaneous daratumumab to KYPROLIS plus dexamethasone will offer increased flexibility and convenience for patients with relapsed or refractory multiple myeloma and will greatly reduce the administration burden," said David M. Reese, M.D., Executive VP of Research and Development at Amgen. Prior to the AACR Meeting, US FDA also gave approval to Carvykti, a chimeric antigen receptor T-cell (CAR-T) therapy from Legend Biotech and Johnson & Johnson (NYSE:JNJ) subsidiary Janssen. In the companies’ CARTITUDE-1 studies, Carvykti provided a deep and durable response rate in 98% of 97 patients. “Today’s approval of CARVYKTI is a pivotal moment for Legend Biotech because it is our first-ever marketing approval, but what really excites us is the drug’s potential to become an impactful therapy option for patients in need of long, treatment-free intervals,” said Ying Huang, Ph.D., CEO and CFO of Legend Biotech. A promising 78% of patients treated achieved stringent complete response, where no cancerous cells could be found in the body, and earlier results showed that after a median follow-up of two years, 74% of those treated were still alive, with 61% having no further progression of their cancer. Article Source: : https://usanewsgroup.com/2020/02/24/why-biotechnology-companies-are-so-important/ DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. (“MIQ”). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles. While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment.
Promising Developments in Treating Multiple Myeloma Coming at This Year’s AACR Meeting March 14, 2022 - Baystreet.ca VANCOUVER – USA News Group –According to a report from ResearchAndMarkets.com, total cases of the uncommon but deadly blood cancer, multiple myeloma, will continue to rise by 2030. Treatment for the condition falls under the Hematological Malignacies Drugs Market, which InsightAce Analytic projects to reach $42.78 billion by 2030, rapidly growing at a CAGR of 13.7% during the forecast period. The Blood Cancer Drugs Market is expected to hit $89.91 billion by 2028, according to a new study by Polaris Market Research. Heading into the American Association for Cancer Research (AACR) Annual Meeting 2022, one of the year’s top meetings on cancer drugs, and coming on the heels of the FDA’s latest approval for Johnson & Johnson’s (NYSE:JNJ) subsidiary’s new therapy, there’s plenty of optimism in the air for multiple myeloma treatment. Now the biotech sector is gearing up to present results at the AACR meeting in this field, including updates from Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), Compugen Ltd. (NASDAQ:CGEN), C4 Therapeutics, Inc. (NASDAQ:CCCC), and Amgen Inc. (NASDAQ:AMGN). One of the presenters set to deliver results at the AACR Annual Meeting in New Orleans between April 8-13, is Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), which has announced phase 1b data demonstrating clinical proof-of-concept for pelareorep-proteasome inhibitor combination therapy in multiple myeloma. Its flagship asset, pelareorep, is an intravenously delivered immunotherapeutic agent that induces anti-cancer immune responses and promotes an inflamed tumor phenotype—turning “cold” tumors “hot”—through innate and adaptive immune responses to treat a variety of cancers. The AACR data are from a completed phase 1b trial evaluating the combination of pelareorep and the proteasome inhibitor bortezomib in relapsed/refractory multiple myeloma patients. Results from the trial showed that the combination was well-tolerated and led to prolonged progression-free survival (PFS) of over three years in a subset of patients. Additionally, biomarker data demonstrated increased infiltration of T and NK cells in the tumor immune microenvironment post-treatment. "To see patients resistant to prior therapies achieve multi-year PFS is a remarkable finding that speaks to pelareorep's potential to synergistically combine with anti-cancer agents and provide sustained clinical benefit," said Kevin Kelly, M.D., Ph.D., Associate Professor of Clinical Medicine at the Keck School of Medicine of the University of Southern California and Principal Investigator of the trial. The AACR data shows post-treatment increases in anti-cancer immune cells correlated with both clinical response and changes in T cell clonality, which has previously been identified as a potential predictive biomarker that could increase the likelihood of success in future trials of pelareorep by informing patient selection. "These are exciting results that we believe bode well for successful outcomes in our two ongoing multiple myeloma studies that are evaluating pelareorep in combination with a next-generation proteasome inhibitor,” said Thomas Heineman, M.D., Ph.D., Chief Medical Officer of Oncolytics Biotech. Back in December 2021, Oncolytics Biotech announced preclinical data demonstrating the drug’s synergistic anti-leukemic effects when combined with the chemotherapeutic agent azacytidine. Oncolytics continues to build on data from the completed multiple myeloma trial through the advancement of two ongoing phase 1 trials of pelareorep in this indication. Also at the AACR Meeting, pioneer in computational target discovery, Compugen Ltd. (NASDAQ:CGEN), is set to present new research suggesting that targeting DNAM-1 axis receptors (PVRIG and TIGIT) holds promise for treatment of multiple myeloma. In particular, the data shows PVRIG is the most dominant immune checkpoint in these patients. "We continue to lead groundbreaking research on the biology of the key targets of the DNAM-1 axis PVRIG and TIGIT,” said Anat Cohen-Dayag, Ph.D., President and CEO of Compugen. “These data support our hypothesis that therapies targeting the DNAM-1 axis may provide new treatment options for certain cancer patients." Clinical-stage biopharmaceutical company C4 Therapeutics, Inc. (NASDAQ:CCCC) will also present a poster and three oral presentations at the meeting. Among their presentations, two pertain to multiple myeloma, including a presentation on the results of the initial treatment cohort from a First-in-Human (FIH) Phase 1/2 Study of its novel IKZF1/3 Degrader, CFT7455. “We look forward to the AACR Annual Meeting, where we will share clinical data from Cohort A in our Phase 1/2 trial evaluating CFT7455 in hematologic malignancies, as well as pre-clinical data from three programs that demonstrate differentiation and versatility of our TORPEDO platform,” said Andrew Hirsch, CEO of C4 Therapeutics. C4T will also present pre-clinical data characterizing the chemical structure of CFT7455 and the resulting improvements in potency and optimized PK properties. Amgen Inc. (NASDAQ:AMGN) has announced that new data from across its oncology portfolio and pipeline will be presented at the meeting, including an abstract on the BiTE Platform, and an evaluation of a dual-targeting BCMA-CS1 HLE BiTE molecule for multiple myeloma. Last December, Amgen received FDA approval for the expansion of the KYPROLIS (carfilzomib) US prescribing information to include its use in combination with DARZALEX FASPRO (daratumumab and hyaluronidase-fihj) and dexamethasone for the treatment of adult patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy. "I am pleased that the addition of subcutaneous daratumumab to KYPROLIS plus dexamethasone will offer increased flexibility and convenience for patients with relapsed or refractory multiple myeloma and will greatly reduce the administration burden," said David M. Reese, M.D., Executive VP of Research and Development at Amgen. Prior to the AACR Meeting, US FDA also gave approval to Carvykti, a chimeric antigen receptor T-cell (CAR-T) therapy from Legend Biotech and Johnson & Johnson (NYSE:JNJ) subsidiary Janssen. In the companies’ CARTITUDE-1 studies, Carvykti provided a deep and durable response rate in 98% of 97 patients. “Today’s approval of CARVYKTI is a pivotal moment for Legend Biotech because it is our first-ever marketing approval, but what really excites us is the drug’s potential to become an impactful therapy option for patients in need of long, treatment-free intervals,” said Ying Huang, Ph.D., CEO and CFO of Legend Biotech. A promising 78% of patients treated achieved stringent complete response, where no cancerous cells could be found in the body, and earlier results showed that after a median follow-up of two years, 74% of those treated were still alive, with 61% having no further progression of their cancer. Article Source: : https://usanewsgroup.com/2020/02/24/why-biotechnology-companies-are-so-important/ DISCLAIMER: Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. (“MIQ”). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice commencing immediately and ongoing. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material, including this article, which is disseminated by MIQ has been approved by Oncolytics Biotech Inc.; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles. While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment.